DetoxiGenomic Profile
 DetoxiGenomic
Profile evaluates single nucleotide polymorphisms (SNPs)
associated with increased risk of impaired detoxification
capacity especially when exposed to environmental
toxins.
It also identifies individuals potentially
susceptible to adverse drug reactions.
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DetoxiGenomic Profile Tests for Phase I: Cytochrome
P-450
• CYP1A1 • CYP2A6 • CYP2E1 • CYP1C19
• CYP1B1 • CYP2D6 • CYP2C9 • CYP3A4
Phase I is the first line of defense in the detoxification
of all environmental toxins, including pesticides, herbicides,
pollutants, and solvents, pharmaceuticals and nutraceuticals,
as well as many of the body’s own waste products (including
steroid hormones).
DetoxiGenomic Profile Tests for Phase II:
Conjugation of Toxins and Elimination
Methylation (catechol-O-methyltransferase)
• COMT
Polymorphisms may lead to impaired metabolism of the
catecholamine neurotransmitters (dopamine, epinephrine, and
norepinephrine) and may predispose individuals to anxiety,
ADHD, alcoholism, and rapid cycling in bipolar individuals.
DetoxiGenomic Profile Tests for Acetylation
(N-acetyl transferase)
• NAT1 • NAT2
NAT detoxifies many environmental toxins, including tobacco
smoke and exhaust fumes. Polymorphisms may result in slow or
rapid acetylation, both associated with increased risk of lung,
colon, bladder, or head & neck cancer.
Glutathione Conjugation (glutathione
s-transferase)
• GSTM1 • GSTT1 • GSTP1
GST detoxifies many water-soluble environmental toxins,
including solvents, herbicides, fungicides, and heavy metals
(eg, mercury, cadmium, and lead). Defects in GST activity can
contribute to fatigue syndromes and many cancers.
DetoxiGenomic Profile Tests for Oxidative Protection
(superoxide dismutase)
• SOD1 • SOD2
Mutations affecting these antioxidant enzymes can lead to
increased free radical activity and cell damage, and may
increase the risk of developing neurodegenerative
disorders.
DetoxiGenomic Profile Specimen
Requirements:
Blood–One 9 ml blood sample in EDTA tube, provided in test
kit.
Sorry this test is not available in New
York.
Turn around time is 21 days.
DetoxiGenomic Profile Information
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DetoxiGenomic Profile Description
DetoxiGenomic Profile Sample Report
DetoxiGenomic Kit Instructions
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