OptiMag 125™

OptiMag 125™ is a proprietary blend of two of Albion®’s highly bioavailable, well-tolerated, patented, true amino acid chelates: Magnesium Glycinate/Lysinate and Di-Magnesium Malate (patent pending).

This formula has been awarded with the Albion® Gold Medallion characterized by research-confirmed, highest bioavailability, outrivaling other preparations on the market. 

Clinical Applications*
• Cardiovascular Health
• Healthy Muscle Function/Healthy Nerve Conduction
• Bone Health
• Support Energy Production
• Support Healthy Blood Sugar
• Correct Dietary Magnesium Deficiency (very prevalent)

Xymogen Online Store
Call 405.936.3333 and get your password to browse and order vitamins, minerals and herbs from our Xymogen Catalog.

Magnesium Glycinate/Lysinate has been subjected to a variety of clinical trials to determine its impact on clinical symptoms and physical performance, as well as its absorption, tolerability and safety.

Among three bioavailability studies is a double-blind one that compared magnesium glycinate/lysinate to magnesium chloride. Eight blood samples drawn over 24 hours and urine specimens gathered four times within that same time period revealed the chelate was absorbed at a rate that was 228% higher than the chloride form; urinary excretion was lower from the chelate compared to the chloride.

In this same study Albion®’s magnesium glycinate/lysinate was also better tolerated and produced a weaker laxative effect than the magnesium chloride.1In general, Albion® patented mineral chelates are resistant to competitive minerals, do not weaken the action of vitamins and pose a smaller risk of overdosing.2

Di-Magnesium Malate, the other chelate in OptiMag 125™, received its patent in 2004 (patent number 6,706,904) as dimetalhydroxymalate. Malic acid was chosen because just as in nature, it forms complexes with magnesium.3By weight, di-magnesium malate contains 69% malate. Each capsule of OptiMag 125™ supplies 350 mg of malic acid. Magnesium and malate play critical roles in energy production under aerobic conditions or when oxygen is lacking.4 Malic acid also appears to be able to chelate aluminum.5

Magnesium, the second most abundant element in the body participates in about 300-350 enzymatic reactions in nearly all tissues. Deficiency is common and results from poor dietary intake, poor absorption and excessive losses through urine, stool, perspiration or lactation; certain drugs, certain herbs, kidney disease, excessive alcohol intake and/or drinking mostly “soft” water. 6

The mineral’s roles in the clinical applications cited above are quite well established. Beyond commonly recognized clinical applications, researchers have demonstrated magnesium deficiency can cause subclinical inflammation in the small intestine producing significant functional changes there and in remote organs, as well as increased sensitivity to oxidative stress.7Children with magnesium intakes less than 75% RDA were 58% more likely to have elevated CRP.8

Long term adequate magnesium intake has been shown to protect against gallstones in men.9Adequate magnesium intake indeed has strong, farreaching health benefits.

All XYMOGEN® Formulas Meet or Exceed cGMP Quality Standards.

References

1. Roussouw J and Brummelen R, The bioavailability of four magnesium supplement preparations, publication pending

2. http://www.albion-an.com/human/archive.htm {accessed 21 Feb 2008}

3. Schell J. Interdependence of pH, malate concentration, and calcium and magnesium concentrations in the xylem sap of beech roots. Tree Physiol. 1997 Jul;17(7):479-83. [PMID: 14759841]

4. Abraham GE, Flechas JD, Management of Fibromyalgia: Rationale for the Use of Magnesium and Malic Acid. Journ of Nutr Med;1992(3)49-59 AA [Albion Research Notes, April 2003]

5. Suzuki T, et al. Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae. Biol Trace Elem Res. 2007 Winter;120(1-3):257-63. [PMID: 17916978]

6. Magnesium Balance, Can You Juggle? Albion Research Notes 2006 Dec; 15(4):1-4

7. Scanian Bj, et al. Intestinal Inflammation Caused By Magnesium Deficiency Alters Basal and Oxidative Stress-Induced Intestinal Function. Mol Cell Biochem, 2007 Dec; 306(1-2):59-69 [PMID: 17657590]

8. King DE, et al. Magnesium intake and serum C-reactive protein levels in children. Magnes Res. 2007 Mar;20(1):32-6 [PMID: 17536486]

9. King D, Mainous A 3rd, Geesey M, Woolson R. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005 Jun 24(3):166-71

10. Tsai CJ, et al. Long-Term Effect of Magnesium Consumption on the Risk of Symptomatic Gallstone Disease Among Men. Am J Gastroenterol, 2007 Dec 12. [PMID: 18076730]

11. Laires MJ, Monteiro CP, Bicho M Role of cellular magnesium in health and human disease. Front Biosci. 2004 Jan 1;9:262-76 [PMID: 14766364]

Consult your healthcare practitioner before using if you take medications, have a medical condition, are pregnant or lactating.

Return from OtiMag 125 to Deitary Supplement Vitamins Minerals and Herbs