OncoPLEX SGS ™ 

OncoPLEX provides Sulphoraphane Nutritional Support for Cancer Risk, Gastritis, H. pylori, Age-related Macular Degeneration, Hypertension, Cardiovascular Inflammation and Arthritis.

Natural Support for:

• Cancer risk, in a variety of sites 7, 9 11, 12, 13, 14, 16      
• Gastritis, H Pylori 15, 16 
• Protection from age-related macular degeneration 17, 18 
• Hypertension 24, 
• Cardiovascular inflammation  19  
• Arthritis  20 

Glucosinolates are of particular interest due to their role in the prevention of cancer and other chronic and degenerative diseases. More than 200 publications throughout the world have underscored the significance of sulforaphane glucosinolates.

Key ingredient : 

Sulforaphane glucosinolate (SGS ™  )-   is a patented form of a potent detoxifying and antioxidant sulfur compound that was isolated in 1992 by researchers at Johns Hopkins School of Medicine. Glucosinolates are present in cruciferous vegetables and especially rich in certain varieties of broccoli and young broccoli sprouts. The human body does not absorb dietary glucosinolates. However, when the plant is cut or chewed glucosinolates are enzymatically hydrolyzed into isothiocyanates (e.g. sulforaphane) and other biologically-active compounds. Intestinal microflora also degrade the glucosinolates into isothiocyanates. 

The pattern of cancer risk reduction observed in hundreds of studies indicates that the breakdown products of glucosinolates may decrease the amount of DNA damage and cell proliferation, as well as block the processes that inhibit apoptosis and stimulate unregulated cell growth.10  The glucosinolates down-regulate the cytochrome p450 (phase 1) carcinogen-producing enzymes. 

OncoPLEX SGS™may be referred to as an "indirect antioxidant" because it is a potent inducer of the body's own phase 2 detoxication enzymes that provide broad-spectrum antioxidant activity that may last for days after the SGS has left the body. Animal studies show SGS protects multiple organs from chemically-induced cancers. 2,3 ,  7,9,11,12,13,14,16 

The Americans diet, generally lower in glucosinolates than diets in other parts of the world, contains about 15-18 mgs.25  Most of the cancer-prevention studies have used a daily dose of 30 mgs of SGS™, the amount in a single capsule of OncoPLEX SGS™. Unlike direct antioxidants, such as vitamins C and E, it is very unlikely that OncoPLEX SGS™ could become a prooxidant.1 

The ability of sulforaphane to induce phase 2 enzymes may also account for its possible supportive role in arthritic joints. These enzymes seem to prevent the activation of the inflammatory COX-2 enzyme.20 

Sulforaphane has been found to be a potent bacteriostatic agent against 3 reference strains and 45 clinical isolates of H. pylori, irrespective of their resistance to conventional antibiotics.14   SGS™ activates antioxidant enzymes in the gastric mucosal that prevent H.Pylori DNA-induced damage.15 

Studies in hypertensive rats have demonstrated that sulforaphane may reduce blood pressure and block the progression of plaque development to strokes by retarding oxidative damage.24 

Contraindications  :  At the time of this writing there have not been anyside effects or drug interactions reported. However, since sulforaphane does interact with drug detoxifying enzymes, individuals taking prescription drugs deserve close evaluation and supervision.23

Xymogen Vitamins are available at Flourish Integrative Pharmacy.

Xymogen Online Store 

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References

1. SGS™ Fact Sheet, Brassica Protection Products LLC Baltimore, MD

2. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8.
3. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94:10367–72.

4. Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149–51 [review]. 

5. Clapper ML, Szarka CE, Pfeiffer GR, et al. Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity. Clin Cancer Res 1997;  3:25 –30.

6. Nijhoff WA, Mulder TP, Verhagen H, et al. Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-alpha and -pi in humans. Carcinogenesis 1995;16:955–7. 

7. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 1994; Apr91:3147-3150.

8. Zhang Y, Talalay P, Cho CG, Posner G. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 1992; Mar 89:2399-2403

9. Smith, TK, Mithen R, Johnson, IT. Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis 2003; 24(3): 491-495

10. Dorothy Rybaczyk-PathakJoint Association of High Cabbage/Sauerkraut Intake at 12-13 Years of Age and Adulthood with Reduced Breast Cancer Risk in Polish Migrant Women: Results from the US Component of the Polish Women’s Health Study (PWHS)
Abstract # 3697. Poster Session C. 7:30 a.m., Wednesday, November 2, 2005.

11. Jackson SJ, Singletary KW. Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization

12. Wang L, Liu D, Ahmed T, Chung FL, Conaway C, Chiao JW. Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol. 2004 Jan;24(1):187-92. PMID: 14654956
13. Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, Lui D. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenographs by apoptosis and cell cycle arrest. Carcinogenesis 2004; 25(8):1403-1408
14. Chaio JW, Chung F-L, Kancherla R, Ahmed T, Mittleman A, Conaway CC. Sulforaphane and its metabolites mediate growth arrest and apoptosis in human prostate cancer cells 
15. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA  . 2002 May 28;99(11):7610- PMID: 12032331
16.  Yanaka, A. Broccoli Sprouts Relieve Gastritis in H. pylori Patients: May Help Prevent Gastric Cancer (Abstract #3442) American Institute for Cancer Research Annual Meeting.  Baltimore  ,  MD  , Poster Session:  7:30 a.m.  Nov 2, 2005
17. Gao X, Talalay P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage . 2004 July 101 (28): 10446-10451 [www.pnas.org/cgi/doi/10.1073/pnas.0403866101]

18. Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. PNAS 2001 Dec 98(26):15221-15226 [www.pnas.org/cgi/doi/10.1073/pnas.261572998]

19. Wu L, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation on the cardiovascular system. 2004, May 101(18):7094-7099 [www.pnas.org/cgi/doi/10.1073/pnas.0402004101]

20. Healy, Z. Proceedings of the National Academy of Sciences 2005, Sept: 102(39): 14010-14025,

21. http://www.broccosprouts.com/health/sgsfactsheet.htm [Accessed 11.4.05] 

22. http://www.food4less.net/hn/Supp/Sulforaphane.htm [Accessed 11.4.05] 

23.  Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett 1997;114:169–70.

24.  Wu L, Noyan Ashraf MH, Facci M, Wang R, Paterson PG, Ferrie A, Juurlink BH. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7094-9. Epub 2004 Apr 21. PMID: 15103025
25.  Milford & Evans (1991) Outlook on Agriculture 20:31-37